Type 2 diabetes mellitus (T2D) is a growing metabolic disorder affecting all age groups and is linked to testiculopathy, a key contributor to male infertility. Testiculopathy disrupts spermatogenesis and the… Click to show full abstract
Type 2 diabetes mellitus (T2D) is a growing metabolic disorder affecting all age groups and is linked to testiculopathy, a key contributor to male infertility. Testiculopathy disrupts spermatogenesis and the sperm microenvironment, with the cyclic adenosine monophosphate (cAMP) response element modulator (CREM) playing a pivotal role in testicular function. Understanding the interplay between T2D and CREM dysregulation is essential for developing targeted therapies for diabetic testicular dysfunction.
Keywords:
testicular dysfunction;
role crem;
crem;
potential role
Journal Title: Reproductive Medicine and Biology
Year Published: 2025
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Journal Title: Reproductive Medicine and Biology
Year Published: 2025
Link to full text (if available)
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recommendations!