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Individualized Net Benefit estimation and meta‐analysis using generalized pairwise comparisons in N‐of‐1 trials

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The Net Benefit (Δ) is a measure of the benefit‐risk balance in clinical trials, based on generalized pairwise comparisons (GPC) using several prioritized outcomes and thresholds of clinical relevance. We… Click to show full abstract

The Net Benefit (Δ) is a measure of the benefit‐risk balance in clinical trials, based on generalized pairwise comparisons (GPC) using several prioritized outcomes and thresholds of clinical relevance. We extended Δ to N‐of‐1 trials, with a focus on patient‐level and population‐level Δ.

Keywords: generalized pairwise; individualized net; net benefit; pairwise comparisons; benefit

Journal Title: Statistics in Medicine
Year Published: 2023

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