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A Robust Method for Perfusable Microvascular Network Formation In Vitro

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Micropost‐based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging.… Click to show full abstract

Micropost‐based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here, how initial seeding parameters determine key characteristics of MVN formation is investigated and a robust two‐step seeding strategy to generate perfusable physiological MVNs in microfluidic devices is established.

Keywords: robust method; microvascular network; perfusable microvascular; formation; method perfusable

Journal Title: Small methods
Year Published: 2022

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