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Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and… Click to show full abstract
Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These PSC‐derived lymphocytes have phenotype and function similar to primary lymphocytes isolated from peripheral blood. PSC‐derived T and NK cells have advantages compared with primary immune cells, as they can be precisely engineered to introduce improved anti‐tumor activity and produced in essentially unlimited numbers. Stem Cells 2018;36:134–145
Journal Title: STEM CELLS
Year Published: 2018
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