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Ebselen was originally developed as a glutathione peroxidase mimic in the treatment of stroke (Parnham & Sies, 2013), and recently explored as a safer alternative to lithium in the treatment… Click to show full abstract
Ebselen was originally developed as a glutathione peroxidase mimic in the treatment of stroke (Parnham & Sies, 2013), and recently explored as a safer alternative to lithium in the treatment of bipolar disorder (Singh et al., 2013). Coincidentally, using magnetic resonance spectroscopy (MRS) we discovered that ebselen reduces glutamate and Glx (glutamate+glutamine) in the anterior cingulate cortex of healthy volunteers (Masaki et al., 2016), consistent with it being an inhibitor of glutaminase enzyme (Thomas et al., 2013).
Keywords:
potential new;
investigating effects;
effects ebselen;
lithium;
glutamate;
ebselen potential
Journal Title: Synapse
Year Published: 2020
Link to full text (if available)
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Journal Title: Synapse
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!