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Effects of treadmill exercise and chronic stress on anxiety‐like behavior, neuronal activity, and oxidative stress in basolateral amygdala in morphine‐treated rats

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The basolateral amygdala (BLA), which is sensitive to stress, is necessary for reward‐seeking behavior and addiction. Regular exercise can produce various positive effects by affecting the BLA. Therefore, we aimed… Click to show full abstract

The basolateral amygdala (BLA), which is sensitive to stress, is necessary for reward‐seeking behavior and addiction. Regular exercise can produce various positive effects by affecting the BLA. Therefore, we aimed to investigate the effects of chronic stress and treadmill running (TR) on anxiety‐like behavior, neuronal activity, lipid peroxidation (measured by malondialdehyde (MDA) levels, a marker for oxidative stress), and total thiol in BLA, in morphine‐treated rats.

Keywords: stress; anxiety like; behavior neuronal; like behavior; basolateral amygdala; chronic stress

Journal Title: Synapse
Year Published: 2022

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