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This review provides a recent overview of the different synthetic routes of the N-CF3 group. This scaffold can be prepared from the desulfurization of thiocabamoyl fluorides or isothiocyanates with fluoride… Click to show full abstract
This review provides a recent overview of the different synthetic routes of the N-CF3 group. This scaffold can be prepared from the desulfurization of thiocabamoyl fluorides or isothiocyanates with fluoride ions. Electrophilic and radical trifluoromethylations are also a great way to generate this motif. This report also focuses on the valorization of some N-CF3 compounds, which leads to new unknown N-trifluoromethyl derivatives. Finally, the first metabolic stability studies will be given for certain structures.
Journal Title: Chemical record
Year Published: 2023
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