Photo by nci from unsplash
Background: Alpha‐ketoglutarate (AKG) or 2‐oxoglutarate is a key substance in the tricarboxylic acid cycle (TCA) and has been known to play an important role in cancerogenesis and tumor progression. Renal… Click to show full abstract
Background: Alpha‐ketoglutarate (AKG) or 2‐oxoglutarate is a key substance in the tricarboxylic acid cycle (TCA) and has been known to play an important role in cancerogenesis and tumor progression. Renal cell carcinoma (RCC) is the most common type of kidney cancer, and it has a high mortality rate. Autophagy is a phenomenon of self‐digestion, and its significance in tumor genesis and progression remains debatable. However, the mechanisms underlying how AKG regulates autophagy in RCC remain unknown. Thus, the purpose of this study was to assess the therapeutic efficacy of AKG and its molecular mechanisms.
Journal Title: Environmental Toxicology
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!