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KCNQ1OT1 sponges miR‐34a to promote malignant progression of malignant melanoma via upregulation of the STAT3/PD‐L1 axis

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Malignant melanoma is a leading cause of skin cancer‐related death. In over 30% of cases, the melanoma is invasive and has a metastatic phenotype. KCNQ1 overlapping transcript 1 (KCNQ1OT1) was… Click to show full abstract

Malignant melanoma is a leading cause of skin cancer‐related death. In over 30% of cases, the melanoma is invasive and has a metastatic phenotype. KCNQ1 overlapping transcript 1 (KCNQ1OT1) was previously identified as an oncogenic long noncoding RNA (lncRNA). Our study intends to uncover the mechanism of KCNQ1OT1 functioning in melanoma.

Keywords: malignant melanoma; melanoma; kcnq1ot1 sponges; 34a promote; mir 34a; sponges mir

Journal Title: Environmental Toxicology
Year Published: 2022

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