LAUSR

World Psychiatry 20:2 June 2021 states may pass citizen-initiated referenda to legalize the medical use of psychedelic mushrooms and plants, such as ibogaine and ayahuasca, by appealing to the putative “entourage” effects of whole plants and the misconception that medicines derived from plants are safer than “synthetic” pharmaceuticals. For all these reasons, we need public funding of independent evaluations of the efficacy of psychedelic drugs. Trials should involve larger numbers of patients who are representative of those clinical disorders for which these drugs may be used, and should include longer-term follow-up evaluations of safety and sustainability of favorable outcomes.