LAUSR

In bacteria, mRNA decay is controlled by megadalton scale macromolecular assemblies called, “RNA degradosomes,” composed of nucleases and other RNA decay associated proteins. Recent advances in bacterial cell biology have shown that RNA degradosomes can assemble into phase‐separated structures, termed bacterial ribonucleoprotein bodies (BR‐bodies), with many analogous properties to eukaryotic processing bodies and stress granules. This review will highlight the functional role that BR‐bodies play in the mRNA decay process through its organization into a membraneless organelle in the bacterial cytoplasm. This review will also highlight the phylogenetic distribution of BR‐bodies across bacterial species, which suggests that these phase‐separated structures are broadly distributed across bacteria, and in evolutionarily related mitochondria and chloroplasts.