Reactions of 3-(2-aminophenyl)-6-R-1,2,4-triazin-5(2H)-ones with aryl isocyanates and aryl isothiocyanates were studied by using solvents of various nature, as well as varying the temperature regime and process duration. The series of… Click to show full abstract
Reactions of 3-(2-aminophenyl)-6-R-1,2,4-triazin-5(2H)-ones with aryl isocyanates and aryl isothiocyanates were studied by using solvents of various nature, as well as varying the temperature regime and process duration. The series of synthesized compounds was shown to exhibit pronounced cytostatic activity with respect to specific cell lines of melanoma, non-small cell lung cancer, kidney cancer, and cancer of central nervous system.
Keywords:
triazin ones;
ones aryl;
triazino quinazolines;
aminophenyl triazin;
quinazolines structure;
activity
Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2018
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Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2018
Link to full text (if available)
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recommendations!