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SYNTHESIS AND FUNCTIONALIZATION OF 2-ALKYLIDENE-5-(BROMOMETHYL)-2,3-DIHYDRO-1,3-THIAZOLE DERIVATIVES

2-Alkylidene-5-methylidene-1,3-thiazolidin-2-ylidenes react with N-bromosuccinimide to form 2-alkylidene-5-(bromomethyl)-2,3-dihydro-1,3-thiazoles, the reaction of which with S,O,N-nucleophiles is used for the selective synthesis of the corresponding 5-methyl-functionalized derivatives. Authors: Mariia B. Litvinchuk, Anton V.… Click to show full abstract

2-Alkylidene-5-methylidene-1,3-thiazolidin-2-ylidenes react with N-bromosuccinimide to form 2-alkylidene-5-(bromomethyl)-2,3-dihydro-1,3-thiazoles, the reaction of which with S,O,N-nucleophiles is used for the selective synthesis of the corresponding 5-methyl-functionalized derivatives. Authors: Mariia B. Litvinchuk, Anton V. Bentya, Nataliia Yu. Slyvka, Mykhailo V. Vovk

Keywords: alkylidene bromomethyl; bromomethyl dihydro; synthesis functionalization

Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2018

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