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Broadly Neutralizing Antibodies to Highly Antigenically Variable Viruses as Templates for Vaccine Design.

Development of vaccines to highly variable viruses such as Human Immunodeficiency Virus and influenza A viruses faces multiple challenges. In this article, these challenges are described and reverse vaccinology approaches… Click to show full abstract

Development of vaccines to highly variable viruses such as Human Immunodeficiency Virus and influenza A viruses faces multiple challenges. In this article, these challenges are described and reverse vaccinology approaches to generate universal vaccines against both pathogens are laid out and compared.

Keywords: antigenically variable; variable viruses; antibodies highly; highly antigenically; neutralizing antibodies; broadly neutralizing

Journal Title: Current topics in microbiology and immunology
Year Published: 2020

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