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Synthesis of NickFects, a New Family of CPPs, by Solid-Phase Peptide Synthesis.

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Cell-penetrating peptides (CPPs) are relatively short peptides that can enter to the cell interior and facilitate intracellular delivery of associated cargo molecules. NickFects is a novel family of CPPs, designed… Click to show full abstract

Cell-penetrating peptides (CPPs) are relatively short peptides that can enter to the cell interior and facilitate intracellular delivery of associated cargo molecules. NickFects is a novel family of CPPs, designed to deliver various types of bio-active cargos using non-covalent nanoparticle formation approach. This chapter describes in details the manual synthesis of cell-penetrating peptides using Fmoc-solid phase peptide synthesis (SPPS).

Keywords: solid phase; peptide synthesis; phase peptide; family cpps; synthesis

Journal Title: Methods in molecular biology
Year Published: 2020

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