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Using INFERNO to Infer the Molecular Mechanisms Underlying Noncoding Genetic Associations.

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The INFERNO method provides an integrative computational framework for characterizing the causal variants, tissue contexts, affected regulatory mechanisms, and target genes underlying noncoding genetic variants associated with any phenotype or… Click to show full abstract

The INFERNO method provides an integrative computational framework for characterizing the causal variants, tissue contexts, affected regulatory mechanisms, and target genes underlying noncoding genetic variants associated with any phenotype or disease of interest. Here we describe the computational steps required to run the full INFERNO pipeline on any dataset of interest.

Keywords: using inferno; infer molecular; underlying noncoding; molecular mechanisms; noncoding genetic; inferno infer

Journal Title: Methods in molecular biology
Year Published: 2021

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