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Computational Methods for Pseudogene Annotation Based on Sequence Homology.

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The number of complete genome sequences explodes more and more with each passing year. Thus, methods for genome annotation need to be honed constantly to handle the deluge of information.… Click to show full abstract

The number of complete genome sequences explodes more and more with each passing year. Thus, methods for genome annotation need to be honed constantly to handle the deluge of information. Annotation of pseudogenes (i.e., gene copies that appear not to make a functional protein) in genomes is a persistent problem; here, we overview pseudogene annotation methods that are based on the detection of sequence homology in genomic DNA.

Keywords: annotation; sequence homology; computational methods; pseudogene annotation

Journal Title: Methods in molecular biology
Year Published: 2021

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