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Liposomes for the Delivery of Lipopeptide Vaccines.

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Liposomes, which are artificial phospholipid vesicles with a bilayer membrane structure, have been developed and evaluated as a promising delivery system for vaccines. Here, we describe a procedure for the… Click to show full abstract

Liposomes, which are artificial phospholipid vesicles with a bilayer membrane structure, have been developed and evaluated as a promising delivery system for vaccines. Here, we describe a procedure for the encapsulation of lipopeptide vaccines into liposomes. A liposomal formulation of lipid-core peptide was prepared via thin-film hydration followed by extrusion. The physicochemical properties of the liposomes, including their size, polydispersity, surface charge, and morphology, were analyzed using dynamic light scattering and transmission electron microscopy.

Keywords: delivery; lipopeptide vaccines; delivery lipopeptide; microscopy; liposomes delivery; vaccines liposomes

Journal Title: Methods in molecular biology
Year Published: 2022

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