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Transcriptional regulatory circuits are often complex, consisting of many components and regulatory interactions. Mathematical modeling is an important tool for understanding the behavior of these circuits, and identifying gaps in… Click to show full abstract
Transcriptional regulatory circuits are often complex, consisting of many components and regulatory interactions. Mathematical modeling is an important tool for understanding the behavior of these circuits, and identifying gaps in our understanding of gene regulation. Ordinary differential equations (ODEs) are a commonly used formalism for constructing mathematical models of complex regulatory networks. Here, I outline the steps involved in developing, parameterizing, and testing an ODE model of a gene regulatory network.
Journal Title: Methods in molecular biology
Year Published: 2017
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