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Determination of Autoantibodies to Transglutaminase by Electrochemiluminescence (ECL) Assay.

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Appearance of autoantibodies to tissue transglutaminase (TGA) is the most reliable biomarker to identify celiac disease autoimmunity. A nonradioactive assay of determination of TGA was newly developed using electrochemiluminescence (ECL)… Click to show full abstract

Appearance of autoantibodies to tissue transglutaminase (TGA) is the most reliable biomarker to identify celiac disease autoimmunity. A nonradioactive assay of determination of TGA was newly developed using electrochemiluminescence (ECL) technology. This ECL assay has been demonstrated to be more sensitive than current standard radio-binding assay (RBA) in detecting TGA and can detect TGA earlier among high-risk young children followed from birth.

Keywords: assay determination; ecl assay; determination autoantibodies; electrochemiluminescence ecl

Journal Title: Methods in molecular biology
Year Published: 2019

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