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Determining virulence factors which contribute to the ability of Proteus mirabilis to establish itself as a prominent cause of urinary tract infections is key in developing targets for potential therapies… Click to show full abstract
Determining virulence factors which contribute to the ability of Proteus mirabilis to establish itself as a prominent cause of urinary tract infections is key in developing targets for potential therapies and treatments. Constructing mutants and testing them in a head-to-head in vivo challenge with the parental strain or other mutants enables determination of what, if any, competitive advantage may exist. Here we describe the methods necessary to ensure successful mouse transurethral inoculation and colonization in a cochallenge infection.
Journal Title: Methods in molecular biology
Year Published: 2019
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