LAUSR

Photochromic molecules can respond to external stimulations and undergo reversible conversion between different chemical structures, providing one photochromic molecule with multiple recognition states for targeting compounds. Here we design a facile sensor microchip with only one photochromic molecule (spirooxazine) to discriminate multiplex metal ions. The sensor chip performs in dark, ultraviolet, or visual stimulation, resulting in different molecular states of spirooxazine-metallic coordination and patterned fluorescent signals for analysis. By using this sensor microchip, 11 metal ions are discriminated. Furthermore, mineral water of 16 different brands and metal ions in human serum are distinguished.