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Putting a New Spin of G-Quadruplex Structure and Binding by Analytical Ultracentrifugation.

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Analytical ultracentrifugation is a powerful biophysical tool that provides information about G-quadruplex structure, stability, and binding reactivity. This chapter provides a simplified explanation of the method, along with examples of… Click to show full abstract

Analytical ultracentrifugation is a powerful biophysical tool that provides information about G-quadruplex structure, stability, and binding reactivity. This chapter provides a simplified explanation of the method, along with examples of how it can be used to characterize G4 formation and to monitor small-molecule binding.

Keywords: analytical ultracentrifugation; quadruplex structure; putting new; new spin

Journal Title: Methods in molecular biology
Year Published: 2019

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