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Hepatoprotective Effect of Trehalose: Insight into Its Mechanisms of Action.

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Trehalose is a nonreducing disaccharide formed by two glucose molecules. It has been shown that trehalose can protect proteins and cellular membranes against the adverse effects of different types of… Click to show full abstract

Trehalose is a nonreducing disaccharide formed by two glucose molecules. It has been shown that trehalose can protect proteins and cellular membranes against the adverse effects of different types of stress, such as dehydration, cold, heat, and oxidation. Chronic liver disease has emerged as an important cause of morbidity and mortality throughout the world. This disaccharide has received attention for its hepatoprotective activities against liver damage. The main mechanisms underlying the hepatoprotective action of trehalose are reducing inflammatory signaling, enhancing antioxidant defense, and induction of autophagy.

Keywords: trehalose insight; insight mechanisms; action; hepatoprotective effect; mechanisms action; effect trehalose

Journal Title: Advances in experimental medicine and biology
Year Published: 2021

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