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A novel multifunctional carbazole–aminoquinoline dimer PZ001 was designed, synthesized, and evaluated. The results indicated that PZ001 possessed selective copper chelation, and inhibited copper-induced Aβ1–42 aggregation. Furthermore, PZ001 exerted powerful neuroprotection… Click to show full abstract
A novel multifunctional carbazole–aminoquinoline dimer PZ001 was designed, synthesized, and evaluated. The results indicated that PZ001 possessed selective copper chelation, and inhibited copper-induced Aβ1–42 aggregation. Furthermore, PZ001 exerted powerful neuroprotection against glutamate-induced HT22 cell death. These results suggest that PZ001 may be a promising multifunctional anti-AD compound.
Keywords:
novel multifunctional;
copper;
multifunctional carbazole;
carbazole aminoquinoline;
aminoquinoline dimer
Journal Title: Medicinal Chemistry Research
Year Published: 2017
Link to full text (if available)
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Journal Title: Medicinal Chemistry Research
Year Published: 2017
Link to full text (if available)
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recommendations!