LAUSR

In order to research the structure–activity relationships of novel naphthalimide derivatives bearing disulfide bond toward antitumor activity, we prepared a series of those and their in vitro antiproliferative activities were screened against human cancer cell lines A549, Hela, SMMC-7721, and normal cell lines L929 by CCK-8 assay. After testing, most of synthesized compounds 5a-i , 6a-i showed better antitumor activity than the positive control 5-fluorouracil. Compounds 5b , 5f , and 5i showed excellent antitumor activity against Hela cells with IC 50 values of 3.64, 3.67, and 3.57 µM, respectively. Compounds 5a , 5b , and 5i exhibited good biological activity to A549 cells with IC 50 values of 5.25, 6.20, and 5.50 respectively. Compared with 5-fluorouracil, all of synthesied compounds showed low cytotoxic effects on normal human cell line L929.