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The coupling of acetylated piperazinylamide spacered triterpenoic oleanolic acid and ursolic acid with meta or para substituted carboxylated malachite green analogs gave conjugates 10 , 11 , 15 , and… Click to show full abstract
The coupling of acetylated piperazinylamide spacered triterpenoic oleanolic acid and ursolic acid with meta or para substituted carboxylated malachite green analogs gave conjugates 10 , 11 , 15 , and 16 that were cytotoxic for several human tumor cell lines. Especially, an oleanolic acid-derived compound 10 was cytotoxic for MCF-7 human breast carcinoma cells (EC 50 = 0.7 μM). These derivatives represent first examples of triterpenoic acid derivatives holding a cationic scaffold derived from malachite green.
Keywords:
ursolic acid;
malachite green;
cytotoxic evaluation;
synthesis cytotoxic;
acid
Journal Title: Medicinal Chemistry Research
Year Published: 2020
Link to full text (if available)
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Journal Title: Medicinal Chemistry Research
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!