LAUSR

Ovarian cancer is one of the main causes of women’s mortality worldwide. A variety of biological mechanisms are involved in ovarian cancer pathogenesis, including epigenetic alterations, mutations (especially in tumor suppressor genes), upregulated oncogenes, decreased apoptotic pathways, and dysregulation of other signaling pathways. Surgery and chemotherapy are two common approaches for treating ovarian cancer. Chemoresistance to common therapeutic drugs results in a lack of significant improvements in ovarian cancer therapy. In this regard, finding and developing new therapeutic platforms are required. Utilizing medicinal plants has emerged as a new horizon in the treatment of various cancers, such as ovarian cancer. Berberine is a yellow extract obtained from different plants and shows various antitumor activities. Also, clinical studies indicated that berberine is a safe and nontoxic compound. Herein, we reviewed the role of berberine in different aspects of ovarian cancers, such as apoptosis.