LAUSR

In this study, glutathione reductase (GR) from baker’s yeast (Saccharomyces cerevisiae) was exposed to 0, 25, 50, 100, 250 and 500 mg/L copper(II) oxide nanoparticles (CuO NPs) and copper(II) chloride (CuCl2). Changes in GR% activity upon exposure to 25, 50, 100, 250 and 500 mg/L CuO NPs and CuCl2 were found to be + 0.3, − 3.4, − 8.1, − 25.7 and − 37.4 and − 60.7, − 72.7, − 77.8, − 85.3 and − 90.6, respectively. The 50% inhibition concentration (IC50) was 625 ppm (78.6 × 10−4 M) for CuO NPs and 21 ppm (1.56 × 10−4 M) for CuCl2. Moreover, CuO NPs and CuCl2 inhibited GR competitively and noncompetitively, respectively.