Despite decades of research investigation, efforts to increase awareness and quality improvement initiatives efforts, morbidity and mortality due to severe sepsis and septic shock remains unacceptably high [1]. There has… Click to show full abstract
Despite decades of research investigation, efforts to increase awareness and quality improvement initiatives efforts, morbidity and mortality due to severe sepsis and septic shock remains unacceptably high [1]. There has been an extensive search for novel adjunctive therapies and treatment strategies not limited to an array of immune-modulatory agents, anti-coagulants, and supportive treatments involving glucose control, fluid therapy, and vasopressor, inotropic, and organ support [2]. While gains in general associated with the outcomes of critical illness have been achieved, improvement in outcomes associated specifically with severe sepsis and septic shock management in recent years has been at best modest...
               
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