LAUSR

1. Acute tubular necrosis is the main histopathologic finding in AKI Acute tubular necrosis (ATN), a histological pattern observed after ischemic insult, is considered the most frequent cause of any form of acute kidney injury (AKI) despite the absence of extensive histological data. This belief derives from previous observations of ATN in biopsies of trauma patients. ATN is, however, uncommon in AKI (Fig. 1) and it does not accurately reflect the morphological changes during prolonged warm ischemia followed by reperfusion [1]. In the majority of cases, AKI in the critically ill patient is a complication of sepsis and major surgery. In such cases, ATN is uncommon (limited and sparse) and other pathophysiological non-ischemic mechanisms are involved as suggested by a lot of experimental data [2].