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Metabolic acidosis is common in critically ill patients and is associated with worse outcomes [1, 2]. Acidemia may lead to decreased myocardial contractility, decreased potency of catecholamine vasopressors and decreased… Click to show full abstract
Metabolic acidosis is common in critically ill patients and is associated with worse outcomes [1, 2]. Acidemia may lead to decreased myocardial contractility, decreased potency of catecholamine vasopressors and decreased blood pressure [3], although the clinical significance of these effects may be variable. The role of sodium bicarbonate in treating metabolic acidosis, however, has been controversial [4]. Most medical textbooks state or imply that among the buffer systems, the bicarbonate buffer system is dominant.
Journal Title: Intensive Care Medicine
Year Published: 2019
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