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World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2019): ESCEO-IOF-SFR-GRIO Symposium Abstracts # International Osteoporosis Foundation and National Osteoporosis Foundation 2019 ESCEO-IOF-SFR-GRIO1 PRODUITS LAITIERS FERMENTÉS ET SANTÉ OSSEUSE E. Biver Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Switzerland, Geneva, Switzerland Les produits laitiers fermentés, tels que le yogourt ou les fromages à pâte molle, constituent des sources alimentaires de calcium, phosphore et protéines, qui influencent la croissance osseuse chez les enfants et adolescents, mais aussi la fragilité osseuse liée à l’âge. Des études longitudinales suggèrent une association bénéfique entre la consommation de produits laitiers fermentés et la perte osseuse post-ménopausique ou le risque de fracture. Au-delà de ces nutriments, les produits laitiers fermentés contiennent des prébiotiques tels que l’inuline et des probiotiques capables de modifier l’absorption intestinale du calcium et possiblement la composition et le métabolisme du microbiote intestinal, qui interfèrent avec le métabolisme osseux. La consommation de produits laitiers fermentés pourrait également être un marqueur de mode de vie « sain » et d’un régime alimentaire équilibré favorisant la santé osseuse. ESCEO-IOF-SFR-GRIO2 OSTEOARTHRITIS: A MATTER OF DIET? J. Sellam Service de rhumatologie, hôpital Saint-Antoine, AP-HP, Sorbonne Université, Paris, France Osteoarthritis (OA) is the most common and frequent joint disease. To date, treatments are only symptomatic and we have no curative drugs. Thus, preventive approaches are crucial to limit OA occurrence The 3 main risk factors of OA are aging, obesity and joint trauma. These 3 risk factors have been associated with OA in many studies. A recent study investigating knee OA on cadaveric skeletons from prehistoric, pre-industrial (1905–1940) and postindustrial (1976–2015) periods has shown that knee OA frequency has frankly increased during the postindustrial period. This increased risk of OA during the postindustrial versus pre industrial period was confirmed after adjustment on body mass index at death and sex (Wallace IJ, et al., PNAS 2018). Thus we have to accept that other factors are involved in the increase of OA prevalence since 40 years. We can suspect the role of environment and especially the role of diet, beyond obesity. Research studies are mainly focused on omega 3 fatty acids and dietary fibers since theirs consumptions are usually below the recommendations. Data are encouraging about the biological and clinical effects of these nutrients but we need to have more data to recommend their consumption in the daily care to specifically improve OA symptoms and to prevent OA. Finally, beyond OA, it seems important that patients follow general recommendations about healthy diet and physical activity. ESCEO-IOF-SFR-GRIO3 OSTEOARTHRITIS: AN INFLAMMATORYDISEASE? F. Eymard Department of rheumatology. AP-HP Henri Mondor Hospital. Créteil, Créteil, France, Cell Growth, Tissue Repair and Regeneration Laboratory (CRRET), UPEC EA 4397/ERL CNRS 9215, Créteil, France Osteoarthritis (OA) is no longer considered as a simple degenerative “wear and tear” disease limited to the cartilage but as a complex disease affecting all joint tissues and involving a low-grade chronic inflammation. Although some frequent clinical signs such as effusion, swelling or local warmth already suggested the involvement of an inflammatory process principally in the OA late stages, several MRI studies now attest to the presence of this inflammation also at early stages, especially in the subchondral bone and synovial membrane. The cytokine profile in OA synovial fluid has also confirmed the presence of this low-grade inflammation. The remaining question is to know whether this inflammatory process is only a marker among others of a complex catabolic process or whether it can also initiate OA lesions. Indeed, although it seems logical to consider inflammation as one of Osteoporosis International (2019) 30 (Suppl 2):S201–S202 https://doi.org/10.1007/s00198-019-04994-9