It is commonplace in analytical chemistry that the unknown is difficult to analyse—and that it is difficult to learn about the unknown without the ability to analyse it. To some… Click to show full abstract
It is commonplace in analytical chemistry that the unknown is difficult to analyse—and that it is difficult to learn about the unknown without the ability to analyse it. To some extent, the development of non-target screening (NTS) methods in liquid chromatography-mass spectrometry (LC-MS) in the past decade seemed to overrule this experience for the field of environmental analysis. And a term like “digital sample freezing” is evidence of this understanding that NTS would provide (almost) complete information on the constituents of an environmental sample. But analytical chemists are well aware that this is a misconception:
               
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