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Helium-assisted enhanced discharge in a hollow needle for high-field asymmetric ion mobility spectrometry (FAIMS)

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A carrier gas mixture of nitrogen and helium has been employed to improve the resolving power at the expense of sensitivity for planar high-field asymmetric ion mobility spectrometry (FAIMS) in… Click to show full abstract

A carrier gas mixture of nitrogen and helium has been employed to improve the resolving power at the expense of sensitivity for planar high-field asymmetric ion mobility spectrometry (FAIMS) in previous work. In this paper, a new hollow needle-to-ring ion source was developed, where the helium and nitrogen enter from the hollow needle and ring, respectively. It was found that the signal strengths of acetone, ethanol, and ethyl acetate increased by 8.5, 2.0, and 3.3 times for helium ratios of 20%, 20%, and 10%, respectively. At the same time, the absolute value of compensation voltage and the number of ion peaks increases. It shows that adding an appropriate helium ratio to nitrogen simultaneously improved the sensitivity and resolving power of planar FAIMS, which is reported for the first time.

Keywords: ion; high field; asymmetric ion; field asymmetric; hollow needle; helium

Journal Title: Analytical and Bioanalytical Chemistry
Year Published: 2021

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