LAUSR

The clinical trial evaluating 5HTTLPR and 5HTTLPR-rs25531 polymorphisms with the treatment response of escitalopram in patients with major depressive disorder deserved comment [1]. Firstly, could Mandal and colleagues provide the trial registration number? According to international guidelines accepted by the Journal in 2008 and detailed in its website, trial registration must be included in the article. Further, a registration of the trial cannot be found in the most commonly used public registry (clinicaltrials.gov). Secondly, the approval of the trial by an Institutional Ethics Committee, a most frequent case, questioned the independency of the decision. Thirdly, how participants were informed that: