LAUSR

Due to their interesting properties for human health, medicinal plants are of worldwide interest, including Iran. More has yet to be investigated and analyzed on the use of methods affecting medicinal plant growth and biochemical properties under stress. The important question about medicinal plants is the purpose of their plantation, determining their growth conditions. The present review article is about the effects of salinity stress on the growth and production of secondary metabolites (SM) in medicinal plants. In stressful conditions including salinity, while the growth of medicinal plants decreases, the production of secondary metabolites (SM) may increase significantly affecting plant medicinal properties. SMs are self-protective substances that medicinal plants quickly accumulate to resist changes in the external environment. Although previous research has indicated the effects of salt stress on the growth and yield of medicinal plants, more has yet to be indicated on how the use of biological methods including plant growth regulators (PGR) and soil microbes (mycorrhizal fungi and plant growth-promoting rhizobacteria, PGPR) may affect the physiology of medicinal plants and the subsequent production of SM in salt stress conditions. The use of modern omics has become significantly important for the identification and characterization of new SM, transcriptomics, genomics, and proteomics of medicinal plants, as well as for the high production of plant-derived medicines. Accordingly, the possible biological mechanisms, which may affect such properties, have been presented. Future research perspectives for the production of medicinal plants in saline fields, using biological methods, have been suggested. KEY POINTS: • The important question about medicinal plants is the purpose of their plantation. • Secondary metabolites (SM) may significantly increase under salinity stress. • Biological methods, affecting the production of SM by stressed medicinal plants.