LAUSR

Purpose To compare image quality and diagnostic performance of three magnetic resonance cholangiopancreatography (MRCP) protocols in patients with suspected pancreatic abnormalities: free-breathing standard 3D-MRCP (STD), free-breathing compressed sensing 3D-MRCP (CS), and CS 3D-MRCP with acquisition during a single breath-hold > 20 s (BH-CS). Methods Informed consent was obtained. We performed 57 MRCPs in 56 prospectively included patients (29 men, median age 59 years). The three protocols were performed in random order. Acquisition time was recorded. Two radiologists blinded to the protocols used 5-point scales to assess image quality parameters (overall image quality, amount of artifacts, background suppression, bile and pancreatic duct visualization) and diagnostic performance (anatomical variants, duct abnormalities, cystic lesions). Results Acquisition time was 279 s with STD, 176 s with CS (-37%), and 22 s with BH-CS (-93%). STD and BH-CS were not significantly different for overall image quality, artifacts, or background suppression. The BH-CS group had fewer non-diagnostic scans (3% vs. 19% with STD and 21% with CS, p  < 0.05), higher-quality scans (78% vs. 66% with STD and 58% with CS, p  < 0.05), and milder artifacts (2% vs. 18% with STD and 16% with CS, p  < 0.05). The main pancreatic duct was better visualized with BH-CS compared to STD ( p  = 0.015) and CS ( p  < 0.001). Diagnostic performance did not differ across the three protocols. There were fewer indeterminate scans in the BH-CS group. Conclusion 3T BH-CS is reliable, saves time, and is not associated with decreases in image quality or diagnostic performance compared to STD and CS.