LAUSR

Purpose The purpose of this study was to investigate the difference between imaging features of ultra-small renal cell carcinoma (usRCC) and angiomyolipoma with minimal fat (mfAML) whose enhancement were both hypervascular by using multidetector computed tomography (MDCT). Materials and methods Confirmed by pathology, 40 cases of hypervascular usRCC and 21 cases of hypervascular mfAML both with diameter of 2 cm or less were compared and analyzed retrospectively, including traditional imaging features and thin-section computed tomography (CT) dynamic enhanced parameters. Meanwhile, receiver operating characteristic (ROC) curves were constructed to evaluate the diagnostic efficacy of each significant parameter and the information with diagnostic value was selected to construct the prediction model. Results Comparison of traditional imaging features: the features, included age, shape, location, central location of tumor, wedge sign, renal cortex lift sign, black star sign, enhanced homogeneity in cortical phase (CP) and enhancement pattern had no significant difference between usRCC and mfAML ( P  > 0.05); sex, cystic degeneration or necrosis, pseudocapsule sign, and enhanced homogeneity in nephrographic phase (NP) had significant differences between usRCC and mfAML ( P  < 0.05). Comparison of CT dynamic enhanced parameters: the CT value, NEV and REV of usRCC were all higher than mfAML in both CP and NP ( P  < 0.01). Respectively, the area under the ROC curve (AUC) were 0.74, 0.75, 0.78, 0.83, 0.81 and 0.78. The sensitivity and specificity for differentiating ucRCC from mfAML were 85.0% and 76.2% respectively when NEV_NP was 73.6 HU as the critical value. Multivariate analysis showed that male, cystic degeneration or necrosis, and NEV_NP higher than 73.6 HU as an independent risk factor for usRCC ( P  < 0.01). The AUC value of the prediction model constructed by the combination was 0.94, the accuracy was 86.89%, the sensitivity was 82.50%, and the specificity was 95.24%. Conclusion Morphological characteristics in traditional diagnosis of small renal carcinoma (diameter of 4 cm or less) have certain significance in differentiating hypervascular usRCC and mfAML in early stage, but the diagnostic efficacy was limited. Sex, cystic degeneration or necrosis, and quantitative parameters measured after enhancement play an important role in differential diagnosis of hypervascular usRCC and mfAML, and the prediction model constructed by the combination has a good diagnostic performance.