LAUSR

The classification of human neurodegenerative diseases, while heavily dependent on neuropathologic analyses, increasingly relies on a number of data sources. Advances in the classification of clinical phenotypes and the expansion of molecular genetic alterations associated with various neurodegenerative diseases provide neuropathologists with additional means to categorize neurodegenerative disease. In the face of increasing data complexity, neuropathologists are poised to serve the critical role of integrating numerous data streams into an integrated autopsy report. I propose here a transition towards an integrated neurodegenerative disease autopsy report where the role of the neuropathologist is to assimilate clinical, molecular and anatomic/morphologic data to provide a succinct, layered diagnosis.