LAUSR

Aims Evaluating the association between serum uric acid levels and biochemical parameters linked to preeclampsia (PE) severity and to adverse perinatal outcomes. Methods Cross-sectional study. Information about gestational and biochemical parameters were collected before delivery, whereas perinatal outcomes were observed after it. Pregnant women were divided into hyperuricemia—HU (uric acid ≥ 6 mg/dL) or normouricemia (uric acid, 2.6–5.9 mg/dL) groups. Poisson regression models (prevalence ratio—PR; 95% confidence interval—95% CI), multinomial logistic regression (odds ratio—OR; 95% CI), and Pearson's correlation (correlation coefficient— r ) were applied by taking into consideration p  < 0.05 as significance level. Results The total sample comprised 267 pregnant women with PE. HU was observed in 25.8% of patients; it was associated with black pregnant women ( p  = 0.014) and with primiparity ( p  = 0.007). Uric acid levels were higher in early PE cases than in late PE cases ( p  = 0.013); however, there was no significant difference between mild and severe PE cases ( p  = 0.121). Uric acid recorded a positive correlation to urea ( p  < 0.001), creatinine ( p  = 0.002), glutamic-oxaloacetic transaminase ( p  < 0.001), glutamic-pyruvic transaminase ( p  = 0.005), ferritin ( p  = 0.002) and globulin ( p  = 0.002); as well as negative correlation to platelets ( p  = 0.035), lactic dehydrogenase ( p  = 0.039) and albumin ( p  > 0.001). HU was a factor associated with cesarean delivery ( p  = 0.030), prematurity ( p  = 0.001), low birth weight ( p  < 0.001) and small for gestational age ( p  = 0.020). Conclusion High serum uric acid levels were associated with early-onset PE. Maternal features were correlated to biochemical parameters linked to PE severity and to adverse perinatal outcomes.