LAUSR

To evaluate a new radiomics strategy that incorporates intratumoral and peritumoral features extracted from lung CT images with ensemble learning for pretreatment prediction of lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD). A total of 105 patients (47 LUSC and 58 LUAD) with pretherapy CT scans were involved in this retrospective study, and were divided into training (n = 73) and testing (n = 32) cohorts. Seven categories of radiomics features involving 3078 metrics in total were extracted from the intra- and peritumoral regions of each patient’s CT data. Student’s t tests in combination with three feature selection methods were adopted for optimal features selection. An ensemble classifier was developed using five common machine learning classifiers with these optimal features. The performance was assessed using both training and testing cohorts, and further compared with that of Visual Geometry Group-16 (VGG-16) deep network for this predictive task. The classification models developed using optimal feature subsets determined from intratumoral region and peritumoral region with the ensemble classifier achieved mean area under the curve (AUC) of 0.87, 0.83 in the training cohort and 0.66, 0.60 in the testing cohort, respectively. The model developed by using the optimal feature subset selected from both intra- and peritumoral regions with the ensemble classifier achieved great performance improvement, with AUC of 0.87 and 0.78 in both cohorts, respectively, which are also superior to that of VGG-16 (AUC of 0.68 in the testing cohort). The proposed new radiomics strategy that extracts image features from the intra- and peritumoral regions with ensemble learning could greatly improve the diagnostic performance for the histological subtype stratification in patients with NSCLC.