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Adjuvant-free schistosome cathepsin L3 is an efficacious schistosomiasis vaccine–comment on Huang et al.: Characteristics and function of cathepsin L3 from Schistosoma japonicum

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Dear Editor: We read with interest the article by Huang et al. (2020) reporting on the Schistosoma japonicum cathepsin L3 gene successful cloning and expression, accurate protein distribution in the… Click to show full abstract

Dear Editor: We read with interest the article by Huang et al. (2020) reporting on the Schistosoma japonicum cathepsin L3 gene successful cloning and expression, accurate protein distribution in the different parasites stages, especially the adult musculature and alimentary canal, and protective capacity against challenge infection. We were nevertheless appalled by the last sentence in the Discussion stating that “SjCL3 is not suitable as an antigen for developing an anti-schistosome vaccine,” and herein show the reasons that led to this incorrect statement.

Keywords: schistosome; schistosoma japonicum; huang; cathepsin

Journal Title: Parasitology Research
Year Published: 2020

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