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A child with arthritis, skin rash, abdominal pain and nephritis: searching beyond Henoch–Schönlein purpura—Answers

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1. Based on clinical presentation, the most likely diagnosis is Henoch–Schönlein purpura (HSP); however, other causes of pauci-immune vasculitis should be considered in the differential diagnosis. 2. The renal biopsy… Click to show full abstract

1. Based on clinical presentation, the most likely diagnosis is Henoch–Schönlein purpura (HSP); however, other causes of pauci-immune vasculitis should be considered in the differential diagnosis. 2. The renal biopsy showed pauci-immune necrotizing and crescentic glomerulonephritis with global glomerulos clerosis, interstitial fibrosis, and tubular atrophy. The glomerulonephritis demonstrated mild activity and moderate chronicity. There was no evidence of immune complexmediated disease. 3. ANCA testing was performed and she tested positive for IgG C-ANCA (anti-proteinase 3), and negative for myeloperoxidase antibodies. 4. Based on renal biopsy and being ANCA positive, the patient was given pulse methylprednisolone, mycophenolate mofetil, and rituximab.

Keywords: sch nlein; nlein purpura; henoch sch; child arthritis

Journal Title: Pediatric Nephrology
Year Published: 2018

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