LAUSR

1. The histological examination revealed calcium-oxalate crystal deposition, as part of systemic oxalosis at the base of ulcerated skin with superficial acute inflammation. 2. Systemic oxalosis appears when glomerular filtration rate (GFR) falls below 30–40 ml/min/1.73 m and results in calcium oxalate depositions in various organs including heart, blood vessels, bone, joints, retina, thyroid gland, and skin. 3. The definitive treatment of primary hyperoxaluria type 1 (PH1) is liver transplantation. In the case of end-stage kidney disease, combined (or sequential) renal and liver transplantation is the only curative modality.