LAUSR

One hundred patients with ischemic heart disease and 70 healthy subjects were on unified regimen. Urine was collected with 4-h proportions during 3–5 days (72–120 h). Each portion of urine was analyzed for macro- (Na, K, P, Cl, Ca, Mg) and microelements (Fe, Cu, Zn, Cr, Cd, V). Temporal structure (biological and hydrometeorological indices) parameters have been estimated by nonlinear least squares method for sinusoidal rhythms and dispersion analysis for nonsinusoidal rhythms. Data of weather indices were received from the hydrometeorological service of the Republic of Armenia in 2015 at 3-h intervals. Statistically significant rhythms were observed in healthy subjects in 91% cases of 593 rhythmological investigations of water-mineral homeostasis. Acrophases of water-mineral homeostasis mostly had individual nature. Healthy subjects’ rhythms of water-mineral excretion were depending on rhythms of hydrometeorological indices and were characterized with significant correlative connections. Acrophases of indices of water-mineral homeostasis mostly were outstripping the acrophases of the rhythms of hydrometeorological indices. Chronostructure of water-mineral homeostasis in patients with ischemic heart disease was characterized with infradian and circadian fluctuations. In case of individuals with ischemic heart disease, statistically significant correlative connections between rhythms of water-mineral excretion and rhythms of hydrometeorological indices differ in comparison with the results of practically healthy individuals. In patients with ischemic heart disease, acrophases of biorhythms often were concurrent or delayed relative to the acrophases of the rhythms of hydrometeorological indices.