LAUSR

we read with interest the recent report by Rowen and Robins regarding the effective treatment for “novel coronavirus” SARS-CoV with ozone therapy [1]. The authors explained the effect of ozone therapy through oxidation of the membrane glycoproteins, where thiol groups in reduced form (R-S-H) are changed to disulphide (R-S-S-H). Then, viral enzymes can become inactive when reduced thiols are oxidized. Coronavirus structure has regions rich in cysteine, which are vulnerable to oxidation. The COVID-19 is real worldwide pandemic with significant morbidity and mortality, so there is an emergency to find many other treatment methods. We fully agree with the authors that in some conditions, in which there are limitations in conventional treatment, oxidation therapy could be useful; however, we would like to share our thoughts and contributions to this report. Another type of oxidation therapy is administration of partially ionized oxygen. Although it is not a frequently used method, its success was proven. Therapy with ionized oxygen (Ionized Oxygen Therapy – IO2Th/Engler) is a physical, adjuvant, short-term medical administration of partially ionized oxygen. This method was developed in 1980 by Assoc. Prof.