LAUSR

TSC (tuberous sclerosis) complex is the major negative regulator of mTOR which activates cell cycle progression leading to uncontrolled growth. Acute leukemias are very heterogeneous as a group of hematological malignancies; they arise as a result of pled up genetic alterations. To study TSC gene expression in acute leukemia patients. Sixty-two Egyptian de no novo adult acute leukemia patients were assessed using SYBR green quantitative PCR as well as 22 controls. Correlation of TSC gene expression with response rate, other prognostic factors, and RFS was assessed. TSC1/TSC2 showed higher gene expression in acute leukemias compared to controls. TSC1 was significantly higher in T-ALL while TSC2 was significantly higher in B-ALL. Expression did not show significant correlation to known prognostic factors. TSC1/TSC2 overexpression might be implicated in the process of leukemogenesis.