LAUSR

Dear Editor, We appreciate the illustrative comments and widened perspective given by D’Allesandris et al. on the subject of preoperative prophylaxis in intracranial tumor surgery. The description of the microbiological features of Cutibacterium (Propionibacterium) acnes, including its antibiotic resistance pattern, highlights the importance of an accurate choice of preoperative antibiotic prophylaxis. As pointed out by D’Allesandris and colleagues, also indolent surgical site infections (SSIs) caused by C. acnes may cause severe consequences for the neurosurgical patient, such as bone flap osteomyelitis and abscesses [1, 2]. In our study, we also found that an accurate antibiotic prophylaxis reduced the risk of SSI and thereby the need for broad-spectrum antibiotic treatment, including vancomycin and imipenem.