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Molecular analysis of Newcastle disease virus isolates reveals a novel XIId subgenotype in Vietnam

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Eight Vietnamese Newcastle disease virus field isolates from 2008–2015 and 3 vaccine specimens were genotyped based on their full F gene sequences and compared to 80 reference strains representing all… Click to show full abstract

Eight Vietnamese Newcastle disease virus field isolates from 2008–2015 and 3 vaccine specimens were genotyped based on their full F gene sequences and compared to 80 reference strains representing all 18 genotypes. Three isolates formed a novel subgenotype XIId, identified for the first time in Vietnam; while the others clustered as follows: four in subgenotypes VIId and VIIh; two in Genotype I; and two in Genotype II. Evolutionary distance calculations confirmed the Vietnamese XIId isolates were distinct from XIIa and XIIb by 0.062–0.070; and from other genotypes by 0.089–0.245. This data demonstrated that a novel XIId subgenotype emerged in Vietnam indicating considerable genetic diversity, thus highlighting the need to implement antigenic matching during vaccination against NDVs.

Keywords: disease virus; subgenotype; novel xiid; xiid subgenotype; xiid; newcastle disease

Journal Title: Archives of Virology
Year Published: 2018

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